| Course Unit Title | PHYSICAL CHEMISTRY |
| Course Unit Code | PHA201 |
| Course Unit Details | Int.M. Pharmacy (Required Courses) - BSc Pharmacy (Required Courses) - |
| Number of ECTS credits allocated | 6 |
| | Learning Outcomes of the course unit | By the end of the course, the students should be able to:- Demonstrate a good knowledge of thermodynamics and chemical kinetics.
- Recognise the basic laws of thermodynamics, as well as the concept of thermodynamic potentials and their role in chemical reactions.
- Explain how different experimental conditions can influence the speed of a chemical reaction.
- Apply mathematical models that can describe the characteristics of a chemical reaction and yield information about the reaction's mechanism and transition states.
- Apply the methods for the determination of physicochemical parameters having an important role in drug action or medicinal preparations, like lipophilicity, polarity, molar refractivity, viscosity, diffusion and solubility.
- Determine the interaction of molecules and light (electromagnetic rays), and explain the basic principles behind spectroscopy and polarimetry and learn how to apply them.
- Describe the method of polarography and explain its application to pharmaceutical analysis.
- Identify interfacial phenomena. Understand adsorption and related phenomena.
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| Mode of Delivery | Face-to-face |
| Prerequisites | PHA101,PHA102 | Co-requisites | NONE |
| Recommended optional program components | NONE |
| Course Contents | · Thermodynamics: Thermodynamic properties of gases and state equation. Collision and kinetic theory of gases. Structure and thermodynamic properties of liquids. Thermodynamic laws. Internal energy, entropy, enthalpy (determination in chemical reactions). Thermochemistry, phase equilibrium.
· Properties of solutions: acids, bases and buffers. Ionisation, pH and pKa. Solutions of non electrolytic systems. Interfaces and colloidal systems. Electrolytic solutions and equilibrium. Osmosis, diffusion, solubility.
· Oxidation and reduction: Oxidation, reduction, oxidative and reductive species. Oxidation number. Oxidative and reductive reactions.
· Kinetics of homogenous reactions: reaction rates, factors influencing reaction rates, reaction mechanisms, Arrhenius equation, activation energy. Transition state theory.
· Crystal structure: The basic types of crystal structure. Monocrystalline and Polycrystalline materials. Crystallographic directions and planes. X-ray Diffraction.
· Photochemistry and spectroscopy: Interactions of radiation with matter. Photochemical reactions. Spectroscopy (UV-vis, IR, 1H NMR)..
Laboratory Work: Individual or small group laboratories. Experiments will include the determination of entropy, the effect of temperature on reaction rates, determination of the partition coefficient, determination of pKa, spectroscopy and the detection of refractive index. |
| Recommended and/or required reading: |
| Textbooks | - «Επίτομη Φυσικοχημεία», Δ.Α. Γιαννακουδάκης, Ζήτη, Θεσσαλονίκη, 1996.
- “Physical Chemistry for the Chemical and Biological Sciences”, R. Chang, University Science Books; 3rd edition.
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| References | |
| Planned learning activities and teaching methods | · Lectures for learning the theory and fundamentals of physical chemistry, where the lecturer explains with specific examples different aspects of the subject and solve specific problems.
· Weekly tutorial handouts and assignments in order to enforce the “every day” studying and prepare the students to readily attend the next class lecture.
· Tutorial sessions (one hour per week), where additional problems related to the lectures are solved and explained d to the students. The students ask further questions on the lectures for better comprehension as well as frequent reviews and discussions.
· Lectures are supplemented by laboratory exercises to investigate, test, and verify the taught principles, laws and methodologies.
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| Assessment methods and criteria | | Coursework | 40% | | Final Exam | 60% |
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| Language of instruction | Greek |
| Work placement(s) | NO |
