Course Details

1. Explain the theory and application of physical and physicochemical techniques in Pharmaceutical Sciences.
2. Develop the knowledge of the stability and control of drug preparations.
3. Apply modern techniques for the preparation of liposomes and cyclodextrin - drug complexation.
4. Apply the freeze drying method in pharmaceutical as well as in food industry.
5. Apply physical lows in Pharmacy for pharmaceutical preparations or for solving pharmaceutical problems.

·  Physics in the service of Pharmaceutical Sciences. Physical and physicochemical phenomena, physical and physicochemical laws and use in pharmacy.
·  Colloidal dispersion systems, types and properties of colloidal systems. Pharmaceutical nanotechnology.
·  Dissolving, solubilizing drug molecules, osmosis and osmotic pressure, diffusion and osmotic properties of the system, surface tension, surfactants, detergents in Pharmaceutical Sciences.
·  Surface and interphase phenomena.
·  Liposomes, use of cyclodextrins.
·  Absorption, adsorption, desorption. Rheology, rheological properties of liquids.
·  Particle size, particle size distribution and measurement. Pharmaceutical dispersion systems.
·  Freeze-drying techniques, applications and use in pharmaceutical sciences.
·  Lipid bilayer liposomes: Preparation, characterisation, stability and methods of drug trapping.
·  Tutorial: Discussion and problem solving.
Laboratory work: Penetration of a membrane by a drug molecule, Determination of optical rotation of sugars, Determination of the critical micelle concentration, Determination of viscosity of a medium, Determination of the mean diameter of particles, Cyclodextrin encapsulation, Liposome preparation.

• B. J. Sandmann, Applied Physical Pharmacy: An introduction of physical chemical principles, McGraw-Hill Medical, 2002.

• P. J. Sinko, Martin’s Physical Pharmacy and Pharmaceutical Sciences, 5th ed., Lippincott Williams & Wilkins, 2005.