Course Details
Course Information Package
| Course Unit Title | INORGANIC & BIOINORGANIC PHARMACEUTICAL CHEMISTRY | ||||||||
| Course Unit Code | PHA302 | ||||||||
| Course Unit Details | Int.M. Pharmacy (Required Courses) - BSc Pharmacy (Required Courses) - | ||||||||
| Number of ECTS credits allocated | 6 | ||||||||
| Learning Outcomes of the course unit | By the end of the course, the students should be able to:
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| Mode of Delivery | Face-to-face | ||||||||
| Prerequisites | PHA101,PHA106 | Co-requisites | NONE | ||||||
| Recommended optional program components | NONE | ||||||||
| Course Contents | · A detailed pharmacochemical presentation of inorganic and organometallic compounds of pharmaceutical interest. · Examination (structure, synthesis-preparation, properties, biological actions, therapeutic and pharmaceutical applications, identification, purity control) of inorganic compounds used in pharmaceutical sciences and of toxicological interest. · The periodic system of elements in relation to their biologic action and toxicity. Metal ions in living systems, trace elements, synergistic and antagonistic effects of metal ions. Drug–metal interactions. Metalloenzymes. Fe, Co, Mo, Mn, Zn and Cu in cell. · Behaviour of various organic molecules, in relation to metal ions from the aspect of bioactivity for drug and antidote development. · Coordinated bonds and synthesis of chelating agents – metal complexes. · Molecular aspect of heavy metal toxicity (As, Sb, Bi, Cd, Pb, Hg, Pt, Au, Ag) natural and industrial pollution, e.g. Minamata disease. Biological and synthetic ligands. Role of some metals in oxidative stress. · Tutorial: Discussion and problem solving. · Laboratory work: Preparation of barium sulphate, Determination of heavy metals in sodium or magnesium sulphate, Preparation and properties of zinc oxide, Preparation of calcium hydrogen phosphate, Qualitative and quantitative analysis of Ba2+ or Sb3+ in a pharmaceutical substance, Complexation of Pb2+ and Cu2+ with EDTA and penicillamine. | ||||||||
| Recommended and/or required reading: | |||||||||
| Textbooks |
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| References |
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| Planned learning activities and teaching methods | The taught part of course is delivered to the students by means of lectures, conducted with the help of computer presentations. Lecture notes and presentations are available through the web for students to use in combination with the textbooks. Lectures are accompanied with tutorials and laboratory work which is carried out in the chemistry laboratory. | ||||||||
| Assessment methods and criteria |
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| Language of instruction | Greek | ||||||||
| Work placement(s) | NO | ||||||||
