Course Details
Course Information Package
| Course Unit Title | MOLECULAR PHARMACOLOGY | ||||||||
| Course Unit Code | PHA306 | ||||||||
| Course Unit Details | Int.M. Pharmacy (Required Courses) - BSc Pharmacy (Required Courses) - | ||||||||
| Number of ECTS credits allocated | 6 | ||||||||
| Learning Outcomes of the course unit | By the end of the course, the students should be able to:
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| Mode of Delivery | Face-to-face | ||||||||
| Prerequisites | PHA207 | Co-requisites | NONE | ||||||
| Recommended optional program components | NONE | ||||||||
| Course Contents | Molecular and biochemical aspects of drug action. Mechanisms of drug action at cellular and molecular level. Drug receptors, nature and structure, drug-receptor interactions, mechanisms of cellular process activation, how the message is received. Types of drug-receptor (drug-enzyme) interactions. Ion channels, G-protein coupled receptors. Action of drugs on proteins. Action of drugs on enzymes. Modulation of enzyme activity, isozymes. Neurotransmitters, hormones. Agonists, antagonists, partial and invert agonists. Drug action on DNA, RNA. Applications of molecular biology and genetic engineering in pharmacy. Stereochemical factors in pharmacological action. Drug metabolizing enzymes. Molecular pharmacology of free radicals. Oxidative stress and resistance of the organism. Cell death, cell necrosis, cell apoptosis-programmed cell death. Drug molecules with improved action on receptors. Fate of drug molecules in the organism, from the molecular pharmacological point of view. Drugs that act without interacting with receptors. Laboratory Work: Individual or small group experiments involving the preparation of liver microsomes, oxidation of hepatic microsomal membranes and action of antioxidants, in vitro metabolism of erythromycin and 4-nitrophenol by microsomes. | ||||||||
| Recommended and/or required reading: | |||||||||
| Textbooks |
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| References |
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| Planned learning activities and teaching methods | The taught part of course is delivered to the students by means of lectures, conducted with the help of computer presentations. Lecture notes and presentations are available through the web for students to use in combination with the textbooks. Lectures are supplemented with laboratory work carried out in a laboratory. | ||||||||
| Assessment methods and criteria |
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| Language of instruction | Greek | ||||||||
| Work placement(s) | NO | ||||||||
