Course Details
Course Information Package
| Course Unit Title | PHARMACEUTICAL CHEMISTRY I | ||||||||
| Course Unit Code | PHA307 | ||||||||
| Course Unit Details | Int.M. Pharmacy (Required Courses) - BSc Pharmacy (Required Courses) - | ||||||||
| Number of ECTS credits allocated | 6 | ||||||||
| Learning Outcomes of the course unit | By the end of the course, the students should be able to:
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| Mode of Delivery | Face-to-face | ||||||||
| Prerequisites | PHA206 | Co-requisites | NONE | ||||||
| Recommended optional program components | NONE | ||||||||
| Course Contents | · A pharmacochemical presentation, including names and structure, synthetic pathways, origin and extraction-isolation, physical, chemical, biological properties, purity control, identification, quantitative determination, uses and doses, of the following groups of drug molecules: vitamins, hormones and related compounds, chemotherapeutics, antibiotics, other antibacterial, antiviral, antiprotozoal and antifungal compounds. Anticancer drugs. Diuretic and other drugs acting on the genitourinary system. Local anaesthetics, antihistaminics (H1, H2, H3), antidiabetics. Drugs acting on the Autonomic Nervous System, cholinergic agonists and antagonists, sympathetic agonists and antagonists, drugs acting on neuromuscular junctions and autonomic ganglia. Drugs acting on the cardiovascular system, blood pressure, dyslipidemias. Atheromatosis and other blood pathologic conditions. Drugs acting on arrhythmias. · Molecular mechanism of action of the above groups, side effects, fate in the organism with emphasis on drug metabolism, structure-activity relationships. (Representative individual compounds used frequently, some compounds important for historical reasons or serving as examples are examined in the above detailed way). · A structure-activity relationship study and conclusions are drawn for each particular compound group. Ways of conversion of each of the important drug molecules in the body (drug metabolism) are studied in details. Emphasis to drugs against diseases of modern societies and those frequently seen in the population. · Laboratory work: Synthesis and quantitative determination of acetylsalicylic acid, Synthesis and identification of benzocaine, Synthesis and identification of tetraethylammonium bromide, Synthesis and identification of a dihydropyridine derivative, use of the Hansztch reaction, Synthesis and identification of paracetamol, Synthesis, identification and quantitative determination of sulphanilamide, Synthesis and identification of hymechromone, Detection of S, N and halogens in organic compounds, Quantitative determination of ascorbic acid, glycerol, nicotinamide, saccharin sodium, procaine hydrochloride, chloramphenicol. | ||||||||
| Recommended and/or required reading: | |||||||||
| Textbooks |
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| References |
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| Planned learning activities and teaching methods | The taught part of course is delivered to the students by means of lectures, conducted with the help of computer presentations. Lecture notes and presentations are available through the web for students to use in combination with the textbooks. Lectures are accompanied with laboratory work which is carried out in the pharmacy laboratory. | ||||||||
| Assessment methods and criteria |
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| Language of instruction | Greek | ||||||||
| Work placement(s) | NO | ||||||||
