Course Details
Course Information Package
Course Unit Title | PHARMACEUTICAL CHEMISTRY II | ||||||||
Course Unit Code | PHA401 | ||||||||
Course Unit Details | Int.M. Pharmacy (Required Courses) - BSc Pharmacy (Required Courses) - | ||||||||
Number of ECTS credits allocated | 6 | ||||||||
Learning Outcomes of the course unit | By the end of the course, the students should be able to:
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Mode of Delivery | Face-to-face | ||||||||
Prerequisites | PHA307 | Co-requisites | NONE | ||||||
Recommended optional program components | NONE | ||||||||
Course Contents | · Synthetic pathways, extraction-isolation, physical, chemical, biological properties, purity and quality control, identification, quantitative determination, molecular mode of action, side effects, fate in the organism - drug metabolism, structure-activity relationships, therapeutic uses and doses of drugs acting on the Central Nervous System, i.e. general anaesthetics, hypnotics, antiepileptics, anxiolytics, neuroleptics (drugs acting against mania and psychoses), antidepressants, centrally acting muscle relaxants, antiparkinsonian drugs. · Drugs acting on neurodegenerative diseases, mainly on Senile Dementia Alzheimer’s type. · Opioids and other centrally acting analgesics. Opioid antagonists. · Introduction to addiction. Agents used in detoxication and addiction therapy. Central nervous system stimulants (purines, niketamide). Drugs acting on migraine, vertigo and emesis, cough, sneezing and hiccups. Drugs affecting appetite and obesity, Cycloogygenase inhibitors, anti-inflammatory agents (non steroidal), analgesics and antipyretics. · Lipoxygenase inhibitors. Psychotoxic and psychedelic drugs. · Tutorial: Discussion and problem solving. · Laboratory work: Synthesis of phenothiaizine, Synthesis of phenytoin, Identification of compounds acting on CNS with Thin Layer Chromatography, Detection of S and Cl (ionic or covalently bonded) in chlorpromazine, Qualitative and quantitative determination of methanol and ethanol by GLC or HPLC, Determination of chlordiazepoxide hydrochloride, Identification of unknown drug by infrared spectroscopy. | ||||||||
Recommended and/or required reading: | |||||||||
Textbooks |
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References |
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Planned learning activities and teaching methods | The taught part of course is delivered to the students by means of lectures, conducted with the help of computer presentations. Lecture notes and presentations are available through the web for students to use in combination with the textbooks. Lectures are accompanied with tutorials and laboratory work which is carried out in the pharmacy laboratory. | ||||||||
Assessment methods and criteria |
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Language of instruction | Greek | ||||||||
Work placement(s) | NO |