Diploma in Pharmacy / Бакалавр (Diploma) в Области Фармацевтического Дела

Course Details

Course Information Package

Course Unit TitlePHARMACEUTICAL CHEMISTRY II
Course Unit CodePHA401
Course Unit DetailsInt.M. Pharmacy (Required Courses) - BSc Pharmacy (Required Courses) -
Number of ECTS credits allocated6
Learning Outcomes of the course unitBy the end of the course, the students should be able to:
  1. Explain the synthesis of the important drug molecules used for pathologic conditions concerning CNS.
  2. Identify the physical and chemical properties of drugs acting on CNS and ways to handle them.
  3. Recognise the biological properties that give the therapeutic potential to this group of drugs.
  4. Distinguish the structural changes (i.e. metabolism) and fate of this group of molecules in the organism, the duration of action, the possibility of biodetoxication or biotoxication.
  5. Analyse the relationships between action and structural and physicochemical characteristics.
  6. Analyse characteristic molecules used illegally as narcotic and addictive agents, from the pharmacochemical point of view.
Mode of DeliveryFace-to-face
PrerequisitesPHA307Co-requisitesNONE
Recommended optional program componentsNONE
Course Contents·  Synthetic pathways, extraction-isolation, physical, chemical, biological properties, purity and quality control, identification, quantitative determination, molecular mode of action, side effects, fate in the organism - drug metabolism, structure-activity relationships, therapeutic uses and doses of drugs acting on the Central Nervous System, i.e. general anaesthetics, hypnotics, antiepileptics, anxiolytics, neuroleptics (drugs acting against mania and psychoses), antidepressants, centrally acting muscle relaxants, antiparkinsonian drugs.
·  Drugs acting on neurodegenerative diseases, mainly on Senile Dementia Alzheimer’s type.
·  Opioids and other centrally acting analgesics. Opioid antagonists.
·  Introduction to addiction. Agents used in detoxication and addiction therapy. Central nervous system stimulants (purines, niketamide). Drugs acting on migraine, vertigo and emesis, cough, sneezing and hiccups. Drugs affecting appetite and obesity, Cycloogygenase inhibitors, anti-inflammatory agents (non steroidal), analgesics and antipyretics.
·  Lipoxygenase inhibitors. Psychotoxic and psychedelic drugs.
·  Tutorial: Discussion and problem solving.
·  Laboratory work: Synthesis of phenothiaizine, Synthesis of phenytoin, Identification of compounds acting on CNS with Thin Layer Chromatography, Detection of S and Cl (ionic or covalently bonded) in chlorpromazine, Qualitative and quantitative determination of methanol and ethanol by GLC or HPLC, Determination of chlordiazepoxide hydrochloride, Identification of unknown drug by infrared spectroscopy.
Recommended and/or required reading:
Textbooks
  • A. Korolkovas, Essentials of Medicinal Chemistry, Wiley International Publications, John Wiley & Sons, 2003.
References
  • D. J. Abraham, Burger’s Medicinal Chemistry and Drug Discovery, vol. 1-8, John Wiley & Sons, 7th ed., 2010.
  • Comprehensive Medicinal Chemistry II, vol. 1-8, Elsevier, 2006.
Planned learning activities and teaching methodsThe taught part of course is delivered to the students by means of lectures, conducted with the help of computer presentations. Lecture notes and presentations are available through the web for students to use in combination with the textbooks.
Lectures are accompanied with tutorials and laboratory work which is carried out in the pharmacy laboratory.
Assessment methods and criteria
Tests20%
Laboratory20%
Final Exam60%
Language of instructionGreek
Work placement(s)NO

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