Diploma in Pharmacy / Бакалавр (Diploma) в Области Фармацевтического Дела

Course Details

Course Information Package

Course Unit TitleINTRODUCTION TO PHARMACEUTICAL BIOTECHNOLOGY
Course Unit CodePHA407
Course Unit Details
Number of ECTS credits allocated6
Learning Outcomes of the course unitBy the end of the course, the students should be able to:
  1. Identify what biotechnology is, its basic rules, applications, contribution to society as a whole and to health and pharmacy in particular.
  2. Recognise the molecular mechanisms of DNA cloning, methods for creating recombinant DNA molecules and applications for diagnosis and treatment of disease.
  3. State the types of DNA library; about genomic library.
  4. Understand PCR applications and DNA fingerprinting.
  5. Distinguish the basics of animal research and tissue culture applications.
  6. Employ the basics of fermentation technology and the manufacturing of commercial biotechnology products.
  7. Employ the legal and ethical perspectives.
Mode of DeliveryFace-to-face
PrerequisitesPHA210,PHA304Co-requisitesNONE
Recommended optional program componentsNONE
Course Contents·  Global significance of biotechnology, categories of biotechnology processes and products.
·  Genomics, proteomics, metabolomics.
·  Essentials of recombinant DNA technology. Production of recombinant DNA, gene mapping, cloning systems and gene libraries.
·  Mutation detection techniques.
·  Protein and enzyme engineering, theory and methods. Production and purification of pharmaceutical proteins and monoclonal antibodies and their applications. Principles of genetic engineering, specific production of agents useful in pharmacy and therapeutics, secondary plant metabolites, vectors of genetic material.
·  Genetic modifications of organisms used in pharmaceutical sciences. Gene knock-out animal models and transgenic animals.
·  Genetic diseases and gene therapy. Pharmacogenetics.
·  Tissue cultures. Cellular assays in drug discovery. Fermentation technology. Bioreactors. From the human genome to new drugs, possible prospects.
·  Ethical issues.
·  Laboratory Work: Cell culture, tissue culture, assay of drug action using hepatocyte cultures, plasmid DNA extraction from bacteria, PCR technique, biofermentation – biofermentors
Recommended and/or required reading:
Textbooks
  • R.D Sindelar, Taylor & Francis, Pharmaceutical Biotechnology, 2002.
  • P. Prave, U. Faust, W. Sittig, D.A. Sukatsch, Basic Biotechnology. A Student’s Guide, VCH Publications, 1987.
References
  • Remington, The science and practice of Pharmacy, 21st ed., Lippincott Williams & Wilkins, 2005.
Planned learning activities and teaching methodsThe taught part of course is delivered to the students by means of lectures, conducted with the help of computer presentations. Lecture notes and presentations are available through the web for students to use in combination with the textbooks.
Lectures are supplemented with laboratory work carried out in the Biology and Biochemistry laboratory.
Assessment methods and criteria
Tests20%
Laboratory work20%
Final Exam60%
Language of instructionGreek
Work placement(s)NO

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