Course Details
Course Information Package
| Course Unit Title | TOXICOLOGY | ||||||||
| Course Unit Code | PHA408 | ||||||||
| Course Unit Details | |||||||||
| Number of ECTS credits allocated | 7 | ||||||||
| Learning Outcomes of the course unit | By the end of the course, the students should be able to:
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| Mode of Delivery | Face-to-face | ||||||||
| Prerequisites | PHA106,PHA405 | Co-requisites | NONE | ||||||
| Recommended optional program components | NONE | ||||||||
| Course Contents | · Acquaintance of biochemical and molecular toxicology. Cellular and molecular mechanisms of the toxic actions of substances, heavy metals, organic solvents, agrochemicals, food additives, environmental pollutants, food poisoning, drugs. Symptoms of poisoning in various tissues and organs, treatment, antidotes. Radiation toxicity, nuclear accidents, radioactive substances disposition. Genotoxic agents, teratogenesis, mutagenesis, fetal toxicity. Doping and doping control. Chemical, biological and nuclear war. Clinical, industrial, environmental, professional, forensic and analytical toxicology. Methods of detecting poisonous agents. Detection of poisons and their metabolites by classical and by instrumental analytical techniques. Detection of function of vital organs, e.g. liver, kidney, in chronic poisoning or too long medication, measuring biochemical parameters, such as SGPT, SGOT, LAD, BUN, creatinine. Toxicokinetics. Determination of lethal dose. Reasons of poisoning, accidental, suicidal, professional, criminal. Professional biological sampling, of sampling air, earth, water reserves, sea water for analytical toxicological reasons. · Laboratory Work: Poisoning by heavy metals, e.g. lead, mercury, and protection by antidotes, e.g. EDTA, dimercaprol; Detection of intoxication by an alkaloid, e.g. atropine, strychnine and protection by general or specific antidotes; Toxicity of organic solvents, e.g. carbon tetrachloride-caused hepatotoxicity and mechanism of the protective action of proadifen. | ||||||||
| Recommended and/or required reading: | |||||||||
| Textbooks |
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| References |
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| Planned learning activities and teaching methods | The taught part of course is delivered to the students by means of lectures, conducted with the help of computer presentations. Lecture notes and presentations are available through the web for students to use in combination with the textbooks. Lectures are supplemented with laboratory work. | ||||||||
| Assessment methods and criteria |
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| Language of instruction | Greek | ||||||||
| Work placement(s) | NO | ||||||||
