Diploma in Pharmacy / Бакалавр (Diploma) в Области Фармацевтического Дела

Course Details

Course Information Package

Course Unit TitleCHEMISTRY & TECHNOLOGY OF INDUSTRIAL PHARMACY
Course Unit CodePHA409
Course Unit Details
Number of ECTS credits allocated5
Learning Outcomes of the course unitBy the end of the course, the students should be able to:
  1. Identify the different sections of pharmaceutical industry and the function of each section.
  2. Recognise the importance of the application of good manufacturing practice.
  3. Recognise the interaction of various sections in a pharmaceutical factory in a harmonious manner.
  4. Recognise how the starting-incoming material must be kept and treated.
  5. State how the final products must be released.
  6. Distinguish the function of the patent section of the company.
  7. Analyse the importance of the research section in a pharmaceutical company for designing and developing new pharmacomolecules and new pharmacotechnological products.
  8. Apply the way a pharmaceutical factory works with the minimal negative effects on the environment.
Mode of DeliveryFace-to-face
PrerequisitesPHA208,PHA402Co-requisitesNONE
Recommended optional program componentsNONE
Course Contents·  Organisation of a pharmaceutical industry: Chemical section, production of the active principle compounds. Formulation section, solid, liquid, injectable forms. Analytical control section. Sterile area.
·  Scaling-up process, from laboratory to pilot plant quantities. Massive production. Problems and solutions of industrial-mass production. Prevention and assessment of trans contamination. Washing and cleaning machines. Sterilization, sterile area, disinfection, control and assessment.
·  Setting of the whole plant. Personnel, education, skills, consciousness, health, health safeguard. Care and protection of the pharmaceutical plant environment. Good manufacturing practice. In vitro and in vivo evaluation of the product quality. Development of novel pharmacotechnological forms and delivery systems. Research section, design of novel molecules, of improved or novel technological products - drug releasing forms. Innovations in analytical methods. Administration and Product promotion sections and follow-up.
·  The patent office for the new molecules and the innovative delivery systems will be presented.
·  Laboratory Work: Visit to pharmaceutical plants. Students, in groups, will stay, observe and then work for 2-3 days in the various sections of the factory; Visit to the state drug control offices and discussion with the officials of each section; Visit to a cosmetic factory or to factory for aromatic products, e.g. essential oils and perfumery business.
Recommended and/or required reading:
Textbooks
  • “Textbook of Industrial Pharmacy: Drug Delivery Systems, and Cosmetic and Herbal Drug Technology”, Orient Longman Publishers, 2008.
  • “Remington. The science and practice of Pharmacy”, 21st ed., Lippincott Williams & Wilkins, 2005, Chapter by J.B. Schwartz “Pharmaceutical Manufacturing”.
References
  • “Theory and Practice of Industrial Pharmacy”, L. Lachman Lieberman, CBS Publishers & Distributors, 2009.
Planned learning activities and teaching methodsThe taught part of course is delivered to the students by means of lectures, conducted with the help of computer presentations. Lecture notes and presentations are available through the web for students to use in combination with the textbooks.
Lectures are supplemented with laboratory work.
Assessment methods and criteria
Tests20%
Laboratory work20%
Final Exam60%
Language of instructionGreek
Work placement(s)NO

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