Course Details
Course Information Package
Course Unit Title | DESIGN,DISCOVERY & DEVELOPMENT OF DRUGS | ||||||||
Course Unit Code | PHA410 | ||||||||
Course Unit Details | |||||||||
Number of ECTS credits allocated | 6 | ||||||||
Learning Outcomes of the course unit | By the end of the course, the students should be able to:
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Mode of Delivery | Face-to-face | ||||||||
Prerequisites | PHA301,PHA401 | Co-requisites | NONE | ||||||
Recommended optional program components | NONE | ||||||||
Course Contents | · Organisation of a pharmaceutical industry: Chemical section, production of the active principle compounds. Formulation section, solid, liquid, injectable forms. Analytical control section. Sterile area. · Scaling-up process, from laboratory to pilot plant quantities. Massive production. Problems and solutions of industrial-mass production. Prevention and assessment of trans contamination. Washing and cleaning machines. Sterilization, sterile area, disinfection, control and assessment. · Setting of the whole plant. Personnel, education, skills, consciousness, health, health safeguard. Care and protection of the pharmaceutical plant environment. Good manufacturing practice. In vitro and in vivo evaluation of the product quality. Development of novel pharmacotechnological forms and delivery systems. Research section, design of novel molecules, of improved or novel technological products - drug releasing forms. Innovations in analytical methods. Administration and Product promotion sections and follow-up. · The patent office for the new molecules and the innovative delivery systems will be presented. · Laboratory Work: Prediction, applying theoretical calculations, of pKa, lipophilicity (log P) and topological polar surface area (TPSA) of bioactive molecules; Find the pharmacophore of local anaesthetics. Show that one of them acquires local anaesthetic action. Discuss the optimisation performed starting from cocaine to common local anaesthetic; Find the pharmacophore of morphine-like analgesics. Demonstrate that one of them has the analgesic activity. Discuss the performed pharmacophore optimisation and indicate the lead compound; Docking of molecules to the active site of receptors; Demonstrate the antimicrobial activity of methylene blue, a synthetic dye; Suggest structural modifications on a centrally acting analgesic in order to restrict its activity to the intestine. Show lack of CNS action; Find a compound that would act as an antidote to paracetamol hepatotoxicity, based on the mechanism of the hepatotoxic action of paracetamol overdose; Synthesis of a compound for protection against paracetamol hepatotoxicity, based on rational drug design. | ||||||||
Recommended and/or required reading: | |||||||||
Textbooks |
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References |
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Planned learning activities and teaching methods | The taught part of course is delivered to the students by means of lectures, conducted with the help of computer presentations. Lecture notes and presentations are available through the web for students to use in combination with the textbooks. Lectures are supplemented with laboratory work. | ||||||||
Assessment methods and criteria |
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Language of instruction | Greek | ||||||||
Work placement(s) | NO |