Course Details

1. Identify the importance and contribution of the sector in advance of medicine and pharmacy and health in general
2. Explain the chemical composition and biological role of the main biomolecules
3. Describe the basic functions of the human body and the metabolism processes
4. Explain the biochemical basis of disease
5. Explain finding from data analysis

·  Introduction to Biochemistry and the basic concepts:
Atoms, biological molecules, chemical bonding, cells and their organization in the body and the organic molecules that are composed
Acidic Solutions, basic solutions and pH. Alkalicity and acidity of chemical and biological solutions. Solutions molarity
Thermodynamics.

·  Proteins:
Amino acids, peptides, polypeptides and protein structure and function
Peptide bonds
Protein 3-D structure
Protein functional and diversity

·  Enzymes:
Enzymatic reactions. Enzyme active site.
Enzymes and diagnosis: clinical applications.

·  Vitamins and Coenzymes

·  Carbohydrates
The role and the function of carbohydrates in the cells
The structure of monosaccharides, disaccharides and polysaccharides
The structure and the role of glucose into cells and metabolism
The structure of lactose, maltose, sucrose, glycogen, starch and cellulose

·  Lipids and Cellular Membranes
The role and the function of lipids in the cells
The structure and function of fatty acids, phospholipids, triglycerides and cholesterol
The structure of cell membrane

·  Metabolism-Energy
Anabolism and catabolism in the human body
The biological modules that store and supply energy to cells
Glycolysis, gluconeogenesis and tricarboxylica acid cycle
Electron transfer and oxidative phoshorylation
Glycogen metabolism. Hormonal regulation of glucose blood level
Metabolism of: fatty acids, cholesterol, amino acids, nucleotides.
Hormonal control and regulation of metabolism
Metabolic disorders

·  Laboratory:
Solution concentration/molarity.
Molecule chemical bonds. Peptide bonds. Glycosidic bonds.
Acids and Bases and pH.
Enzymatic reactions. Pepsin and protein breakdown.Μetabolism.
Medical Biochemistry (Case studies)

• Jeremy M . Berg , John L . Tymoczko , Lubert Stryer , “Βιοχημεία”, Τόμος Ι, Επιστημονική επιμέλεια: Αζαρίας Καραμανλίδης, Πανεπιστημιακές Εκδόσεις Κρήτης, 2005

• Koolman, Jan, “Εγχειρίδιο Βιοχημείας“, Ιατρικές Εκδόσεις Πασχαλίδης, 2007
• Loffler, Georg, “Βασικές Αρχές Βιοχημείας με στοιχεία Παθοβιοχημείας“, Ιατρικές Εκδόσεις Πασχαλίδης, 2007

The taught part of course is delivered to the students by means of lectures, conducted with the help of computer presentations. Lecture notes and presentations are available through the web for students to use in combination with the textbooks.

Lectures are supplemented with laboratory work. During laboratory sessions, students are demonstrating everything that was taught in the lecture sessions.