Synthesis, formulation and evaluation of Pharmaceuticals (SFEP)

The main research interests of the Synthesis, formulation and evaluation of Pharmaceuticals (SFEP) Research Team are: 

• Preparation of polymeric systems with the ability for microphase separation, leading to the formation of well-organized nanomorphologies in solution and in the solid state and the evaluation of polymeric materials to act as delivery systems for drugs and biological molecules.
• Preparation of polymeric nanomaterials of pharmaceutical interest
• Study of the coordination chemistry of radiometals with new donor atom systems for synthesis of new stable building blocks with the required physicochemical properties for the preparation of pharmacologically active compounds.
• Design, synthesis, characterization and evaluation of pharmacologically active complexes that bear on the one hand the coordinated radiometal (building blocks) and on the other the desired pharmacophore group that gives pharmacological activity.
• Design, synthesis and evaluation of compounds with pleiotropic activity.
• Structure-activity relationship study of antioxidant and/or anti-inflammatory derivatives.
• Agents against inflammation, oxidative stress, metabolic syndrome, cardiovascular diseases and neurodegenerative disorders.
• In vivo, in vitro and toxicological evaluation of compounds with pharmaceutical interest.